Cellular Respiration Simulator — Aerobic glucose oxidation, Consumed glucose & Consumed O₂ Interactive

Separate glycolysis in the cytosol, pyruvate oxidation and the citric-acid cycle in the matrix, and electron transport on the mitochondrial inner membrane.

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About this tool — how it works & FAQ

About the Cellular Respiration Simulator

Separate glycolysis in the cytosol, pyruvate oxidation and the citric-acid cycle in the matrix, and electron transport on the mitochondrial inner membrane. Follow carriers, proton pumping and ATP synthase.

What the simulator shows

• 3D scene parts: Cytosolic glycolysis; mitochondrial membranes / cristae; matrix citric-acid cycle; electron-transport complexes; atp synthase. • Controls: Relative glucose supply (0–1 fraction); Relative oxygen supply (0–1 fraction); Block electron transport. • Live readouts: Aerobic glucose oxidation (units/s); Consumed glucose (units); Consumed O₂ (units); Idealized ATP production (units). • Guided experiments: No oxygen; ETC inhibitor. • Four tabs (visual laboratory, curves and measurements, experiments, learn and assess), a model-verification run, a timestamped event log and a trial report.

The model equations

C₆H₁₂O₆ + 6O₂ → 6CO₂ + 6H₂O Rate = min(glucose availability, oxygen availability) Stated ideal yield: 4 substrate-level + 28 oxidative = 32 ATP/glucose

Model limits and how to explore

Molecular geometry, organelle dimensions and animation time are enlarged and illustrative. Colors identify structures rather than natural tissue color. This is a conceptual teaching model, not a cell physiology predictor. Fixed 32 ATP per glucose is an ideal accounting convention; actual eukaryotic yields vary (often about 30–32) with shuttles and losses. Inhibition stops the modeled aerobic throughput; fermentation and independent glycolytic ATP are not solved. Try the preset experiments, then compare the live readouts with the equations.

Frequently asked questions

Does the animation show literal molecular dimensions and timing?

No. Geometry is enlarged and time is a teaching playback scale.

Is the ATP yield always exactly 32 in real cells?

No.

What does this simulator not model?

Molecular geometry, organelle dimensions and animation time are enlarged and illustrative. Colors identify structures rather than natural tissue color. This is a conceptual teaching model, not a cell physiology predictor. Fixed 32 ATP per glucose is an ideal accounting convention; actual eukaryotic yields vary (often about 30–32) with shuttles and losses. Inhibition stops the modeled aerobic throughput; fermentation and independent glycolytic ATP are not solved.

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